Choline phosphate
choline chloride O-(dihydrogen phosphate)
CAS: 107-73-3
Molecular Formula: C5H15ClNO4P
Choline phosphate - Names and Identifiers
| Name | choline chloride O-(dihydrogen phosphate) |
| Synonyms | PHOSPHOCHOLINE Phosphocholine Choline phosphate phosphorylcholine O-Phosphonocholine trimethyl-(2-phosphonooxyethyl)azanium choline chloride O-(dihydrogen phosphate) N,N,N-Trimethyl-2-(phosphonooxy)ethanaminium N,N,N-trimethyl-2-(phosphonooxy)ethanaminium trimethyl[2-(phosphonooxy)ethyl]ammonium chloride N,N,N-trimethyl-2-(phosphonooxy)ethanaminium chloride |
| CAS | 107-73-3 |
| EINECS | 203-516-6 |
| InChI | InChI=1/C5H14NO4P.ClH/c1-6(2,3)4-5-10-11(7,8)9;/h4-5H2,1-3H3,(H-,7,8,9);1H |
Choline phosphate - Physico-chemical Properties
| Molecular Formula | C5H15ClNO4P |
| Molar Mass | 219.6 |
| Melting Point | 108-111 °C (decomp) |
| Boling Point | 103 °C(Press: 12 Torr) |
| Solubility | Methanol (Slightly), Water (Sparingly) |
| Appearance | Oil |
| Color | Colourless |
| Storage Condition | Inert atmosphere,Room Temperature |
| Physical and Chemical Properties | Choline phosphate is also known as Choline phosphate. White Crystal or crystalline powder, slightly fish odor. Melting point 200~205 ℃ (sealed tube). Deliquescence. It is insoluble in benzene, chloroform and ether and other general organic solvents, slightly soluble in ethanol and acetone, soluble in methanol, soluble in water, 10% aqueous solution pH = 4.8~5.0. Toxicity: mouse oral ld507720 mg/kg. The choline chloride is reacted with a methanol solution of sodium hydroxide, and the produced choline is obtained by neutralization with phosphoric acid. Japanese as an additive for synthetic wine, can increase the flavor. The above information was compiled by Xiaogang. |
| Use | This product is for scientific research only and shall not be used for other purposes. |
Choline phosphate - Reference Information
| main uses of choline phosphate | choline phosphate is mainly used as a food additive, used as a quality improver for brewed products, added to synthetic sake, can increase concentrated alcohol aroma; It can stabilize amino acids and other wine ingredients; It can also be used as a seasoning to increase the flavor of dishes. |
| Cytidine diphosphate choline | Cytidine diphosphate choline is a naturally occurring nucleotide, one of the coenzymes in lecithin biosynthesis. It has a stimulating effect on brain circulation. It is obtained by heating choline phosphate with cytidine phosphate amide and dicyclohexyl salt in o-chlorophenol at 100 ℃, or cytidine diphosphate ethanolamine obtained by reacting cytidine diphosphate with azacyclopropane, and then interacting with methyl iodide under alkaline conditions. |
| medicinal properties and applications | phosphate choline is a drug for the treatment of hepatitis. It can participate in the synthesis of phospholipids and has the effects of protecting liver, strengthening liver, promoting lipid metabolism and anti-fatty liver. This product can accelerate methyl transfer, supply activated methyl, and accelerate liver cell regeneration. Choline phosphate can also provide acetylcholine in the body, improve the nutrition and function of autonomic nerves; decompose histamine, enhance histamine activity in the kidney, and have a certain detoxification effect. Clinically, choline phosphate is mainly used for the treatment of acute jaundice or non-icteric hepatitis, chronic persistent and active hepatitis; it is also used for the treatment of liver poisoning, liver fatty infiltration or fatty liver, and liver cirrhosis. |
| Preparation method | 1. In a concentrated aqueous solution of ethylene oxide, trimethylamine is reacted with it at room temperature to make choline. Or in the presence of potassium hydroxide, use methyl iodide to methylate ethanolamine at room temperature to make choline. Then the choline made above is dissolved in methanol, and the choline methanol solution is neutralized with phosphoric acid to generate choline phosphate. After concentration and drying, a crude product of choline phosphate can be obtained. The crude product is dissolved in methanol solution, and then acetone is added to obtain precipitation. After filtration and separation, a finished product of choline phosphate can be prepared. 2. Choline chloride is metathesis in methanol solution of sodium hydroxide. After choline is prepared, choline phosphate can be prepared by reacting with phosphoric acid. Reference materials: Editor-in-Chief An Jiaju; Bao Wenchu, Wang Boying, Li Shunping. Practical fine chemical dictionary. Beijing: China Light Industry Press. |
| identification test | take 5ml of 5% sample aqueous solution and add 1ml of potassium mercury iodide test solution (TS-139) to generate a slightly blue light yellow precipitate. Take 5ml of 5% sample aqueous solution, add 1ml of sodium hydroxide test solution (TS-224) and 0.5ml of potassium permanganate test solution (TS-193), and heat it to produce a smell similar to trimethylamine. This gas can turn moist red litmus test paper blue. Phosphate test (I-26) positive. |
| content analysis | accurately weigh about 0.3g of the sample pre-dried at 110 ℃ for 3h, and analyze it according to the general Kjeldahl nitrogen determination method. 0.05mol/L sulfuric acid per ml is equivalent to 20.116 mg of choline phosphate (C5H16NO5P). |
| toxicity | LD5072g,/kg (mouse, oral). ADI is not restricted (FAO/WHO,2001). |
| usage limit | GB 2760-96: meat products 1 g/kg; GMP for peeling fruits and vegetables. Japan stipulates that 0.2g/L sake. It shall not be used for food other than synthetic sake. The salts produced by the reaction of choline acid and organic alkali have a delicate taste, so they can be used as flavoring agents. |
Last Update：2024-04-09 21:54:55
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